ISC may refer to:
International Science Council - An international non-governmental organization that serves as the global voice for science.
Information Security Conference - A conference that focuses on information security, including topics such as cybersecurity, data protection, and privacy.
Indian School Certificate - An examination conducted by the Council for the Indian School Certificate Examinations (CISCE) for students in India.
Internet Systems Consortium - A non-profit organization responsible for maintaining several key internet infrastructure technologies, including BIND DNS software and DHCP server software.
Integrated Supply Chain - The coordination of all activities involved in producing and delivering a product or service to customers.
Inter-Services Intelligence - Pakistan’s premier intelligence agency responsible for national security issues both domestically and abroad.
